WAGR Syndrome is a rare genetic disorder that affects children from birth. It is a condition that severely affects a person's quality of life due to many abnormalities caused from the disorder. The underlying cause of the condition is the abnormality of chromosome 11, resulting in missing or faulty surrounding genes.The syndrome begins at birth, with the child being diagnosed with one or more of three conditions: aniridia, genitourina malformations (GU), and/or mental retardation. Having one or more of these conditions is considered as having the AGR disorder. People born with AGR have a significantly higher risk of developing a Wilm's tumor. With the development of this tumor, the condition then becomes known as WAGR.Congenital anomalies of the genitals and the urinary tract are known as genitourina malformations (GU). This condition is detected in the perinatal stages. This condition can cause complications such as impaired renal function, sexual dysfunction, or urinary tract infections.
The Wilm's tumor, also known as Nephroblastoma, is a cancer of the kidneys. This is the most common form of cancer among children. Although the disease is intense, the survival rate from this tumor is high being as much as 87% for patients in stage 5 of the disorder.
